Supply CAS 613-93-4 N-Methylbenzamide Raw Material Anti-Cancer
- Avan
- 24/01/2024 13:05
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Company name
Hoyan Pharmaceutical (Wuhan) Co., Ltd
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Healthcare, Pharmacy
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Full time
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Education
Higher
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Supply CAS 613-93-4 N-Methylbenzamide Raw Material Anti-Cancer
N-methylbenzamide is an effective phosphodiesterase 10A (pde10a) inhibitor. N-methylbenzamide has anticancer activity.PDE10A is a recently identified phosphodiesterase with a quite remarkable localization since the protein is abundant only in brain tissue. Based on this unique localization, research has focused extensively on using PDE10A modulators as a novel therapeutic approach for dysfunction in the basal ganglia circuit including Parkinson’s disease, Huntington’s disease, schizophrenia, addiction and obsessive compulsive disorder. Medicinal chemistry efforts identified the N-methyl-N-[4-(quinolin-2-ylmethoxy)-phenyl]-isonicotinamide as a nanomolar PDE10A inhibitor. A subsequent Lead-optimization program identified analogous N-methylanilides and their corresponding N-methylbenzamide as potent PDE10A inhibitors, concurrently some interesting and unexpected binding modes were identified. -
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Supply CAS 613-93-4 N-Methylbenzamide Raw Material Anti-Cancer
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